Acanthopanax against tacrine-induced acute liver injury in rats.docVIP

 PAGE \* MERGEFORMAT 5 Acanthopanax against tacrine-induced acute liver injury in rats [Abstract] of Acanthopanax right of Tacrine-induced acute liver injury in rats. [Methods] fed mice were given 35mg/kg of Tacrine produced acute liver injury model, a daily gavage were given to mice of different doses of total saponins of Acanthopanax senticosus and the crude polysaccharide, continuous 4d, the mice serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and tumor necrosis factor (TNF-α ) activity changes. [Results] Different doses of Acanthopanax total saponin and polysaccharide may reduce the acute liver injury in mice serum AST, ALT, ALP, TNF-α activity, and silymarin was no significant difference. [Conclusion] Acanthopanax right of Tacrine-induced acute liver injury have some protective effect. [Keywords:] Acanthopanax genus; Tacrine; silymarin; liver disease; mice Acanthopanax as a drug has been widely used in clinical, with the strengths of the strong effect. In recent years, domestic and foreign scholars in Acanthopanax the chemical composition, pharmacological effects and clinical applications in areas such as a more in-depth study, but on the five barbed plus protective effect against liver injury in rare reports. This observed Acanthopanax right of Tacrine-induced acute liver injury in rats, the application is designed to provide more Acanthopanax basis. 1 Materials 1.1 Laboratory Animals Kunming mice were obtained from the Department of Yanbian University Medical Experimental Animal Section, weight 20 ~ 22g, were male .25 ℃ constant temperature environment, feeding, fed with standard feed. 1.2 Drugs and reagents were purchased from silymarin Pharmaceutical and Biological Products Institution, batch of 050,603; Acanthopanax purchased from big pharmacy drugs Yanji City, Jilin Province, from Yanbian University Teaching and Research Department of Pharmacognosy School of Pharmacy, Professor Liu Yong