Acute brain injury in endothelin and nitric oxide clinical significance of changes.docVIP

 PAGE \* MERGEFORMAT 9 Acute brain injury in endothelin and nitric oxide clinical significance of changes Study: Reassessing Bai Xiaohong, Chen, Guan Jing, Shang Chuan Wei [Abstract] Objective To investigate the factor of acute brain injury vasomotor changes. Determined in patients with acute cerebral vascular disease, plasma endothelin and nitric oxide levels. Results in patients with acute brain injury in plasma endothelin and nitric oxide changed significantly in the control group significant difference, cerebral infarction was significantly higher than that of plasma ET is also brain injury group (the former P lt;0.01 which P lt;0.05). Conclusions Patients with acute brain injury in the abnormal vasomotor factor, while the ET and NO changes and the closely related to the disease pathology. [Keywords:] acute brain injury, endothelin, nitric oxide Nitric oxide (NO is a vascular relaxing factor, with a strong relaxation of vascular smooth muscle. Endothelin (ET is secreted by the endothelial cells with a strong vasoconstriction in the active material, the main role is to shrink blood vessels and regulate blood flow, blood pressure have important implications, and the wide range of biological effects. ET is the strongest known biological vasoactive peptide [1]. The factors of vasomotor regulation of blood supply to tissues and organs of cells, in the ischemia / reperfusion injury plays an important role. acute brain injury, brain ischemia, and later often secondary to cerebral edema, blood in these patients we are NO and ET changes were observed to investigate the cerebral ischemia / reperfusion injury in the pathophysiology process. 1 Materials and Methods 1.1 Observation of the object Traumatic brain injury group of 35 patients, 31 patients were male and 4 females. Aged 16 to 72 years, the average age of 36.8 years. Infarction 46 cases, 36 cases were male and 10 females. Aged 42 to 86 years, mean age of 66.3 years. two groups of patient