Acute cerebral infarction the level of neuron-specific enolase and its clinical significance.docVIP

 PAGE \* MERGEFORMAT 8 Acute cerebral infarction the level of neuron-specific enolase and its clinical significance [Keywords:] acute cerebral infarction; neuron specific enolase; infarct size; cognitive dysfunction Of acute cerebral infarction (ACI) is often accompanied by high morbidity and mortality rate, so the clinician and the prognosis of their disease development very seriously. Neuron-specific enolase in (NSE) is an intracellular protein, specifically in the nerve cells and neuroendocrine cells. When the ischemia, hypoxia, poisoning or injury, the integrity of cell membrane damage, NSE begins with cells released. Animal experiments showed that the NSE can be used to determine the cerebrospinal fluid in acute cerebral infarction the extent of brain damage and identify the reusable nature of the brain changes with non-complex, which is a lot of modern imaging techniques such as CT, magnetic resonance imaging can not be replaced by (1). This detected 206 cases of ACI serum NSE level of ACI condition of their clinical significance and prognosis. 1 Subjects and methods 1.1 The object of study from January 2008 to December 2009 ACI patients hospitalized in our department of 206 cases, 112 cases of male and female 94 cases, aged 48 to 79 (mean (52.3 + -2.8)) old. Duration of 4 ~ 24 h; are consistent with the Fourth National Cerebrovascular Disease Conference revised standard (2), and by the head CT and (or) MRI confirmed. the normal control group for the same period in our hospital 120 cases of healthy people, evenly divided between men and women of them, aged 50 80 (mean (55.3 + -2.1)) years, excluding cardiovascular disease, diabetes and a recent infection, serious liver and kidney dysfunction and injury were. ACI group was admitted to hospital the next morning and the normal control group, the early morning fasting venous examination Blood serum was separated analytes save. According to clinical neurological deficit scoring (3) The severity of