Acute pancreatitis-associated lung injury in the pathogenesis and prevention of the progress.docVIP

 PAGE \* MERGEFORMAT 12 Acute pancreatitis-associated lung injury in the pathogenesis and prevention of the progress Keywords:: Acute pancreatitis-associated lung injury in neutrophil Acute lung injury with acute pancreatitis (AP), especially in severe acute pancreatitis (ASP) a common complication, and mortality was significantly correlated. In this paper, the pathogenesis of lung injury in AP and control to make a brief review. A neutrophil lung injury and acute pancreatitis In recent years, many studies have shown that, AP lung injury and lung tissue accumulation of a large number of neutrophils, activation, producing a large number of pro-inflammatory cytokines related. Jen et al [1] Application of 99mTc labeled white blood cells to the AP distribution of neutrophils have been studied and found that within the lung tissue in ASP neutrophils increased significantly. Bhatia et al [2] to non-choline and B sparse acid adequate diet (CDE)-induced pancreatitis as a model of female rats, the application of anti-neutrophil serum to remove circulating in neutrophils, was found by the The treatment of animals is not only significantly reduced the severity of pancreatitis, but also completely prevented the occurrence of lung injury. These results suggest that, AP, when activated neutrophil-mediated lung injury played a key role. Neutrophils and endothelial cell adhesion is the initial phenomenon of inflammatory response is its basis for the organization to further migration human lung, but also caused neutrophil endothelial cells, lung tissue injury. Neutrophil cell surface adhesion molecule CD11b/CD18 and endothelial cells in the corresponding ligands intercellular adhesion molecule -1 (ICAM-1) of the knot all in the neutrophil - endothelial cell adhesion play a key role. Some scholars have used rat model of acute hemorrhagic necrotizing pancreatitis (AHNP) study the ICAM-1 expression in lung tissue as well as with the accumulation of neutrophils in the lungs re