Acute promyelocytic leukemia clinical observation of 18 cases.docVIP

 PAGE \* MERGEFORMAT 7 Acute promyelocytic leukemia clinical observation of 18 cases [Abstract] Objective To observe the arsenious acid (AS2O3, all-trans retinoic acid (ATRA combined with chemotherapy in sequential treatment of adult acute promyelocytic leukemia (APL effect. Methods 18 patients with APL were treated with ATRA and arsenic trioxide (there patients with high white blood cell sedimentation, to give the joint daunorubicin induction, consolidation and maintenance therapy, and periodically testing PML_RARa fusion gene. The results complete remission (CR rate was 87.5%, CR, median time of 26d, and the consolidation of the treatment period using ATRA and anthracycline AS2O3 and alternate drugs, and in order to maintain the treatment, the total course of 3 years. has been discontinued in 12 cases, 13 cases were detected every 3 months, both PML-RARa fusion gene (-, 3 patients in the maintenance treatment phase. Only 2 patients died of a cerebral hemorrhage less than CR. Conclusion AS2O3 with ATRA combined with chemotherapy in the treatment of adult APL satisfactory efficacy. [Keywords:] acute promyelocytic leukemia, Adult drug therapy combined Adult acute promyelocytic leukemia (APL is a special type of myeloid leukemia, which is characterized by severe bleeding tendency, complicated by disseminated intravascular coagulation (DIC), led to early death in patients. We arsenious acid (AS2O3, all-trans retinoic acid (ATRA combined with chemotherapy in newly diagnosed 18 cases of APL patients to obtain more satisfactory results are reported below. 1 Materials and Methods 1.1 Clinical data 18 cases of APL are in our department from September 2006 to May 2009 were treated untreated patients, 12 males and 6 females, aged 15-74 years old. Clinical manifestations of varying degrees of pale, skin ecchymosis, which 16 cases of fever, splenomegaly in 8 cases, liver in 2 cases, swollen lymph nodes in 2 cases, the median blood HB 65 (30-92g / L