Adhesion molecules in the role of follicular development.docVIP

 PAGE \* MERGEFORMAT 14 Adhesion molecules in the role of follicular development Keywords: adhesion molecule E-cadherin extracellular matrix in follicular development Cell adhesion molecules (cell adhesion molecules, CAMs) are a class of cell surface glycoprotein-mediated cell-cell, cell and extracellular matrix interactions. In their embryonic development and differentiation of normal tissue structure maintenance, inflammation and immune response, wound repair, blood clotting, and tumor progression and metastasis of a variety of physiological and pathological processes all have an important role. Cell adhesion molecules has gradually become a hot topic of research in the field. In recent years, the cell adhesion molecules in the reproductive role of research has made some progress, this paper, cell adhesion molecules in follicular development and the role of regulation to make a brief review. The types and biological characteristics of Members of the large number of CAMs have been found more than 50, divided into the following five families: 1, E-cadherin (cadherin) family of Called the calcium-dependent cell adhesion molecule (calciumdependent cell adhesion molecule), including E-cadherin (epithelial cells found in adults), N-cadherin (nerve and muscle cells found in adults), and P-cadherin (mainly seen in the placenta and epithelial tissues, developmental stages can also be found in other organizations). Mainly involved in cadherin-mediated cell adhesion the same type of role, so they morphogenesis in the regulation of body processes and to maintain the structural integrity of adult tissues with the polarity has an important role. Widely distributed in various types of cell surface and its adhesion with the pro-homology, ie homology of E-cadherin expression in the cell adhesion will occur [1]. Second, integrins (integrin) family of Is a group of cell surface glycoprotein and its acid body is the extracellular matrix (extracellular matix, ECM) compone