P2X7受体____杨艳.pdfVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2014, 36(5): 561–569 DOI: 10.11844/cjcb.2014.05.9002 特约综述 本实验室的研究工作主要集中在两个方面: (1)病理性疼痛的外周和脊髓敏 化机制, 重点关注背根神经节初级感觉神经元在骨癌痛外周敏化中的作用 和脊髓背角神经元与胶质细胞相互作用在慢性痛中枢敏化中的作用; (2)慢 性痛诱发负性情绪和相关记忆的细胞和分子机制, 重点关注前扣带皮层在 神经损伤和炎症痛引起的抑郁样情绪中的作用。 /web_site/html/member-1.htm /Ch/team_view.asp?ID=10 P2X7受体在病理性疼痛中的研究进展 杨 艳 张玉秋* (复旦大学神经生物学研究所, 上海 200032) 摘要 病理性疼痛主要包括组织损伤或炎症引起的炎症痛、神经系统损伤或疾病引起的神 经病理性疼痛和恶性肿瘤及治疗引起的癌症痛三大类。病理性疼痛对常规的镇痛药物反应不理想, 迫切需要寻找新的对病理性疼痛更有效和更特异的治疗手段。P2X7受体作为离子通道型嘌呤能 受体, 在炎症痛、神经病理性疼痛和癌症痛中都具有重要作用。靶向P2X7受体的新药物将为病理 性疼痛的治疗带来新的希望。该文综述了P2X7受体在三类病理性疼痛中的研究进展。 关键词 P2X7受体; 炎症痛; 神经病理性疼痛; 癌症痛 Progress of P2X7 Receptor Research in Chronic Pain Yang Yan, Zhang Yuqiu* (Institute of Neurobiology, Fudan University, Shanghai 200032, China) Abstract Pathological pain can be usefully divided into three categories, in? ammatory pain, a pain related to peripheral tissue damage/in? ammation, neuropathic pain, pain mainly associated with peripheral nerve injury or illness, and cancer pain, pain induced by tumors in? ltrating/metastasizing and resulting from treatment. Treatment of chronic pain is always accompanied by a poor response, thus, effective therapeutic strategy is imminently needed. P2X7 receptor is one of the purinergic receptors, and belongs to ligand gating non selective ion channel. Numerous studies imply a critical role of P2X7 receptor in chronic pain. Targeting to P2X7 receptor will be a new approach for treatment of pathological pain. In this paper, we reviewed the progress of P2X7 receptor in chronic pain. Key words P2X7 re