ADSORPTION blood uric acid uric acid and reduce the role of.docVIP

 PAGE \* MERGEFORMAT 16 ADSORPTION blood uric acid uric acid and reduce the role of Of: Li Juntao, Zhangyin Li, Ma Jie group, Gao Jie, Wang Shu, Liu Jing, Yong-Xiao Cao [Abstract] Objective To study the adsorption of uric acid and lower montmorillonite role of uric acid. Methods of in vitro adsorption of montmorillonite on uric acid, hyperuricemia with a mouse model of montmorillonite reduces the role of serum uric acid, with phosphotungstic acid uric acid reduction method. Results montmorillonite in simulated intestinal fluid absorption of uric acid has a strong role, and the adsorption was concentration dependent with the same concentrations of montmorillonite (20g / L) on different concentrations of uric acid in the adsorption rate is not very different, the adsorption time curve shows rapid absorption rate of more than half an hour 60%, 1h after the equilibrium was achieved, in the acidic environment (pH 2-6) absorption rate, alkaline environment (pH 8-10) the adsorption rate. uric acid in the blood uric acid levels in mice fed and intestinal concentration of uric acid in the stomach with the montmorillonite decreased with increasing dose, caused by acute intraperitoneal injection of uric acid in the blood uric acid disease model, the montmorillonite group fed the blood uric acid concentration was significantly lower than the untreated group. Conclusion montmorillonite significant role in the adsorption of uric acid and hyperuricemia model can reduce the blood uric acid level in mice. [Keywords:] uric acid, montmorillonite, hyperuricemia, mice ABSTRACT: Objective To evaluate the effects of montmorillonite in adsorbing uric acid and decreasing the concentration of uric acid in serum. Methods The adsorbing effect of montmorillonite was observed in vitro and the effect of decreasing serum concentration of uric acid was studied on acute hyperuricemia model mice . The concentration of uric acid was measured by the reduction method of phosphotungstic