Aging Kidney-Yang Deficiency spectral analysis of differentially expressed genes.docVIP

 PAGE \* MERGEFORMAT 15 Aging Kidney-Yang Deficiency spectral analysis of differentially expressed genes Author: Li Wei Philip Tan Xiao-Jia Yong Fan Huai-chang Zhang days from the e-e WANG Mi-qu [Abstract] Objective using gene chip technology to analyze the occurrence of Aging Kidney-Yang Deficiency and the link between abnormal gene expression. Methods filter Kidney-Yang Deficiency Patients 3 and normal controls 3, using the U.S. Affymetrix’s HG-u133Plus 2.0 gene chip, through the comparison between the two groups, filtering out the aging of differentially expressed genes in patients with kidney yang deficiency. The results of a comparative analysis of inter-chip data sets acquired after 34 differentially expressed genes, clustering analysis has been six differentially expressed genes characteristic manner, mainly involving the cell cycle and apoptosis, tumorigenesis and immunity. Conclusion aging deficiency permits a series of immune disorders involving the complex process of aging may be related to the individual there is a close correlation. [Keywords:] Kidney-Yang Deficiency of differentially expressed genes immunosenescence Abstract: ObjectiveTo explore the relevance between aged kidney-Yang deficiency syndrome and the differentially expressed genes by cDNA arrary.MethodsThree kidney-Yang deficiency patients and three healthy people were selected as samples during the epidemiologic survey of the kidney-Yang deficiency syndrome. The differentially expressed genes were screened by applying HG-u133Plus2.0 of Affymetrix GeneChip.Results34 common differentially expressed genes were obtained after comparison between patients and healthy peoples. 6 differentially expressed genes which are related to cell cycle, apoptosis, tumorigenesis and immunity were obtained by cluster analysis.ConclusionThe aged kidney-Yang deficiency syndrome is related to the dysfunction of the immune system, may be closed related to body ageing as well. Keywords:: kidney-Yang defici