中医药治疗小儿慢鼻渊疗效的Meta_分析.docVIP

*贵阳中医学院科研基金2011(07 )号 第一作者：徐献梅:主管中药师。研究方向：医院制剂。E-mail:523353953@ 中医药治疗小儿慢鼻渊疗效的Meta-分析* 徐献梅1, 杨亮1 （1. 贵阳中医学院第二附属医院, 贵阳市 550001） 摘 要：目的：评价中医药治疗小儿慢鼻渊的临床疗效。方法：通过数据库检索文献，运用随机对照试验评估表对文献进行评估，采用改良Jadad质量评分表对文献进行评价，用 RevMan 5. 2.1 软件包进行Meta分析。结果：共有6 篇随机对照试验共计1114例患者满足纳入标准，异质性检验P=0.58，表明6个研究数据具有同质性，故采用固定效应模型。合并效应量OR=5.59，95%CI（3.62，8.61）；Z=7.79（P0.00001），中医药疗法相对于西药治疗小儿慢鼻渊，具有较好的临床疗效。结论：现有临床证据表明，中医药治疗小儿慢鼻渊有效。但系统评价纳入的RCT均属低质量文献，其疗效须进一步开展大规模的高质量临床试验研究来验证。 关键词：小儿慢鼻渊；小儿慢性鼻窦炎；中医疗法；系统评价；Meta分析 A Meta-analysis: Efficacy of T.C.M. Therapy for Pediatric Chronic Sinusitis# XU Xianmei1, YANG Liang1 (1. No. 2 Hospital Affiliated to T.C.M. College of Guiyang, Guiyang 550001) ABSTRACT objective: To assess the efficacy of T.C.M. therapy for pediatric chronic sinusitis. Methods: Relevant literatures were reviewed via database and assessed via randomized controlled trial (RCT) scale. All reviewed literatures were assessed via Improved Jadad quality scale. Data statistical analyses were performed by RevMan 5.2.1 software. RESULTS: Six pieces of collected articles of RCT were evaluated (including 1114 patients). The test for heterogeneity: P = 0.58, indicating these 6 data had homogeneity, so we applied the fixed effect model. OR = 5.59, 95%CI (3.62, 8.61); Z = 7.79 (P0.00001). The T.C.M. therapy were better than the western medicine in treating pediatric chronic sinusitis. Conclusion: The T.C.M. therapy is possibly effective for pediatric chronic sinusitis. However, because of lower methodological quality of all the trials, the conclusions need to be interpreted cautiously, and more well designed and high quality RCTs need to be performed. KEY WORDS：Pediatric chronic sinusitis; Pediatric chronic sinusitis;T.C.M. therapy; Systematic review; Meta-analysis 慢性鼻窦炎（Chronic nasosinusitis）临属于中医学“慢鼻渊”的范畴，《素问·气厥论篇》曰：“胆移热于脑，则辛頞鼻渊。鼻渊者，浊涕不止也。”本病一年四季皆可发病，且多见于少年儿童。发病后常因患儿有鼻塞，头昏，头痛，腹胀，纳呆等症状而严重影响生长发育[1]。近年来，中医药在小儿慢性鼻窦炎的治疗过程中显示了独特的优势，但目前尚未见相关系统评价研究。本研究旨在对国内外公开发表的中医药治