And molecular targeted therapy of cancer.docVIP

 PAGE \* MERGEFORMAT 15 And molecular targeted therapy of cancer [Keywords:] cancer; targeted therapy With progress in molecular biology, and molecular mechanisms of cancer occurrence and development of in-depth research, cancer targeted therapy in cancer treatment has begun playing an increasingly important area of #8203;#8203;effect. As against a targeted therapy drugs kinds of malignant tissue and cell-specific targets to be attacked, so detection of the presence of cancer tissue in the corresponding targeted molecular target for drug action, has become the clinicians treating cancer patients based on the implementation of targeted drugs. Here’s the relevant cancer target detection and application of targeted therapy and progress to make an introduction. 1 The concept of molecular targeted therapy In recent years, due to the biology of the tumor has penetrated into the molecular level [1 ~ 5], types of cancer, gene mutation and overexpression, and loss of tumor suppressor gene inactivation, gene transcription and protein products of abnormal signal transduction abnormal activation, cell cycle regulation out of control and many other aspects of the factors leading to apoptosis in human cells inhibited the formation of tumor cell proliferation and thus out of control in all aspects has been a lot of research and study and find out the development and progression of cancer involves the abnormal molecules as targets, the design and development for these known drugs that target specific molecules, namely, molecular targeted drugs, these drugs with chemotherapy is different. chemotherapeutic targets is inhibited by the rapid proliferation of tumor cells DNA synthesis , which is commonly referred to as “cytotoxic” effect on normal cells will have a considerable degree of adverse reactions. and molecular targeted therapy for cancer is the process of cellular genes, receptors or transduction of the critical enzyme, Therefore, targeted therapy and chemothe