And the business side of the peace of mind cardiomyocyte apoptosis in rats with chronic heart failure of.docVIP

 PAGE \* MERGEFORMAT 8 And the business side of the peace of mind cardiomyocyte apoptosis in rats with chronic heart failure of Authors: Li Yongmin, Wang Bao-Xing strong, thin Aihua, Wu Ying-Shuang, Zhouning [Abstract] Objective To observe the peace of mind and the business side of chronic heart failure rat cardiac myocytes apoptosis. A large number of ways to subcutaneous injection of isoproterenol (ISO) method of preparation of chronic heart failure in rats were randomly divided into model control group, captopril group, Shen Mai injection group, and business peace of mind large, medium and low-dose group. Separate the normal control group, using TUNEL assay apoptosis of myocardial cells, using immunohistochemistry to detect myocardial cells Bax, Bcl  2 protein expression, calculate the ratio of Bcl  2/Bax. Results In the model control group, TUNEL method cardiomyocyte apoptosis serious brown nuclei increased significantly, immunohistochemical image analysis Bax expression was significantly increased, Bcl  2, Bcl  2/Bax ratio decreased significantly. Compared with the model control group, and the camp safe side groups significantly reduced the number of cardiomyocyte apoptosis, Bax protein expression significantly decreased, Bcl  2, Bcl  2/Bax ratio increased significantly. Conclusions and business peace of mind side by suppressing cardiomyocyte apoptosis in rats with chronic heart failure role. [Keywords:] and business peace of mind party; heart failure; apoptosis; hemodynamics Abstract: ObjectiveTo study the effects of Heyingansxin Fang on myocardial apoptosis in chronic congestive heart failure rats.MethodsAnimal model of heart failure was induced by subcutaneously injecting large dose of ISO and the rats were randomly divided into model group, captopril group, Shenmai injection group, high dosage of Heyinganxin Fang, middle dosage of Heyinganxin Fang, small dosage of Heyinganxin Fang and normal group. Apoptosis was detected with TUNEL. The