Androgen-independent prostate cancer research.docVIP

 PAGE \* MERGEFORMAT 59 Androgen-independent prostate cancer research [Keywords:] prostate cancer, androgen [Keywords:] prostate cancer, androgen Prostate cancer (PCa) is the European and American men, one of the most common malignant tumor. With the aging population in China Raise the level of and diagnosis, PCa incidence is also significantly higher trend. Clinical application of prostate-specific antigen (PS A) post-test, PCa detection rate increased significantly. For the limitations of PCa, application of radiation and surgery to take Have a better efficacy, but there is transfer of PCa is the lack of effective treatment measures. In 1941 Huggins, and Hodge s first discovered PCa cells to stimulate the growth of androgen-dependent proposed androgen blockade therapy PCa, surgery or medication to Potential to become the gold standard for treatment of advanced PCa. However, androgen therapy is difficult to prevent completely blocked the PCa progression of the disease, Will occur in some patients the treatment of androgen-insensitive. Clinically, it usually will be applied, but the disease completely blocked androgen The progress of prostate cancer is still known as the androgen-independent prostate cancer (AIPC). In this paper, the incidence of AIPC Machine System and the treatment of research to be reviewed. An androgen-independent prostate cancer pathogenesis Prostate cancer is a heterogeneous disease, which by the androgen-dependent to androgen-dependent changes in the mechanism are still Not very clear, research focused on the following aspects. 1.1 The androgen receptor (AR) mutation and the occurrence of AIPCAIPC closely with AR mutations, AR in AI PC development process did not disappear [1,2], but also in androgen get rid of PCa recurrence after treatment of anti-AR While amplification [3,4], and thus speculated that AR can raise the level of tumor cells in the ring of low androgen Throughout the growth. However, Radm