Chinese Herb Medicine Parkinson model of melatonin on apoptosis in rat forebrain and striatum of behavior.docVIP

 PAGE \* MERGEFORMAT 13 Chinese Herb Medicine Parkinson model of melatonin on apoptosis in rat forebrain and striatum of behavior Study: Man-Ti Miao Yanli Rong Zhou Yaping Wang Lin, Zhang Ye Xian Xu Jin Rong Zhou Zhiqiang Liu Yiren Division Di [Abstract] Objective To observe the effect of (Pingchan side) combined melatonin (MT of Parkinson’s disease (PD) rat model of behavior and striatal apoptosis in the forebrain, and to explore traditional Chinese medicine combined the role of MT and the treatment of PD its mechanism. Methods 60 SD rats were divided into 5 groups: control group, model control group, MT group, herbal group, herbal + MT group. model control group and each treatment group N rats and 4-methyl benzene based 1,2,3,6 tetrahydropyridine (MPTP PD model established with the climbing pole maze test measurement method and behavioral changes in rats and mental conditions, Bax / Bcl 2 immunohistochemical staining and Tunel assay forebrain striated apoptotic body. Results PD rats had decreased ability to varying degrees, pole climbing and mental decline, and pathological control group, experimental group, especially Chinese medicine + MT group behavior abnormalities may be part or all of the improvements (P lt;0.05 , forebrain striatal neurons and glial cells significantly increased Bcl 2 expression (P lt;0.01, Bax gene expression was inhibited (P lt;0.01, while forebrain nigrostriatal pathway of apoptosis decreased (P lt;0.01 . Conclusion MT medicine Pingchan prescription combined approach by oxidative stress, activation of Bax / Bcl 2 system, regulate forebrain dopamine nigrostriatal pathway (DA neural activity, inhibition of apoptosis and improvement of PD symptoms. [Keywords:] Chinese Pingchan side, melatonin, N-methyl 4-phenyl 1,2,3,6 tetrahydropyridine, apoptosis, Parkinson’s disease Parkinson’s disease (PD) in Chinese medicine as “chatter card, flutter”, the liver and kidney deficiency in the elderly, marrow lack of action within the vir