Chinese Minority Candidate Genes of Essential Hypertension.docVIP

 PAGE \* MERGEFORMAT 17 Chinese Minority Candidate Genes of Essential Hypertension [Key Words] essential hypertension, candidate gene Essential hypertension (EH) is the role of genetic factors and environment of multi-gene genetic diseases, with a high degree of genetic heterogeneity, late dominant and incomplete nature of susceptibility gene exons, which is to determine the relevant genes with EH to great difficulties. EH candidate has been the cause of the importance of scientific research personnel, in which the relationship between race and EH early attention. sampling survey found that the same region and among different peoples in different parts of the prevalence of hypertension among the same ethnic differences (1) In 1991 the Third National sample survey of hypertension, Yi lowest prevalence (3.28%, higher for the Korean (22.95%, Tibetan (21.04% and Mongolian (20.22% (2). the geographical distribution of the various nationalities, customs, economic and cultural as well as vastly different genetic background, as the cause of the EH study provides a unique on-site, over the years researchers from a number of different perspectives on minority were our candidate gene of EH. The so-called candidate genes that encode proteins involved in blood pressure regulation, the gene can be used as candidate genes. This paper is closely related with blood pressure regulation of several candidate genes research progress of ethnic minorities in China are reviewed. 1 renin-angiotensin system (RAS RAS is a strong vasoconstrictor substance angiotensin (angiotensin , Ang in blood pressure regulation system for the center, in the maintenance of water and salt balance and regulation play an important role in cardiovascular activity. In the rate-limiting enzyme renin and angiotensin converting enzyme ( ACE), respectively, under the influence of angiotensinogen (AGT) turn into Ang , Ang , the latter with Ang receptor (ATR) combined, through various mechanisms or