Chinese Weichangshu on gastrointestinal motility disorder caused by atropine gastrointestinal motility in mice.docVIP

 PAGE \* MERGEFORMAT 11 Chinese Weichangshu on gastrointestinal motility disorder caused by atropine gastrointestinal motility in mice Of: Guo Jinxiu, Wang Zhui Well, Liumeng An [Abstract] Objective To observe Weichangshu on gastrointestinal motility disorder caused by atropine gastrointestinal motility in mice, and to explore its mechanism. Methods The mice were randomly divided into control group, model group, atropine, gastric intestinal Shu + atropine group, cisapride + atropine group, woody Shun Qi Wan + atropine group. The subjects were treated with equal volume of liquid intragastric administration 5 d, 18 h after fasting, 6 days in normal saline control group, other groups were injected atropine sulfate injection gastrointestinal motility disorder induced animal model for blue dextran (BD) 2000 as a marker to observe the gastric emptying rate and rate of intestinal propulsion. Results Weichangshu, cisapride and woody Shun Qi Wan on gastrointestinal motility disorder caused by atropine, gastric emptying and intestinal propulsion in the animal significantly promoted (P lt;0.01). Conclusion medicine Weichangshu possibly through the mechanism of film against the M receptor antagonist atropine on the role of the gastrointestinal tract to promote excitatory neurotransmitter acetylcholine secretion, thereby promoting gastrointestinal motility. [Keywords:] gastrointestinal motility disorder Weichangshu injection of atropine sulfate tablets Abstract: ObjectiveTo observe the effect of Weichangshu on gastrointestinal motility disorder caused by Atropine in mice, and to explore its mechanism.MethodsKunming mice were randomly divided into blank control group, model group atropine, Weichangshu + atropine group, cisapride + atropine group, Muxiangshunqi Pills + atropine group. Subjects were orally treated for 5 d.After fasting for 18 h, blank control group was intraperitoneally injected on the sixth day, saline and other groups were injected atropine sulfa