Chronic renal failure on renal capsules renal interstitial fibrosis.docVIP

 PAGE \* MERGEFORMAT 10 Chronic renal failure on renal capsules renal interstitial fibrosis Of: Li Lotus, Li Shuju, Wang eras, Yu Zhuo, Zhang Peiqing [Abstract] Objective To observe the renal capsule to improve the role of renal interstitial fibrosis. Methods adenine suspension rat model of renal failure, renal capsule by traditional Chinese medicine, observation of serum creatinine (SCr), blood urea nitrogen (BUN ), transforming growth factor (TGF-β1) and pathological changes. Results renal capsule group and Niaoduqing group, significantly lower SCr, BUN (P lt;0.05), a significant reduction in kidney tissue of TGF-β1 expression (P lt; 0.05), improvement of renal fibrosis. Conclusion Chronic renal capsule renal failure on renal interstitial fibrosis have a therapeutic effect. [Keywords:] renal capsule, chronic renal failure, renal interstitial fibrosis, animal models Chronic renal failure (CRF) is caused by chronic kidney disease with impaired renal function, renal disease progress to the mechanism of CRF has not been fully clarified, but recent studies have shown that renal interstitial lesions and CRF progress closely, almost all renal diseases progress to renal failure will occur with end-stage renal fibrosis. 1 Materials and methods 1.1 Animals Used male Wistar rats weighing 200 ~ 240 g, were purchased from Heilongjiang University of Chinese Medicine Laboratory Animal Center. 1.2 Drugs and reagents Renal capsule, 0.5 g / grain, Heilongjiang Academy of Traditional Chinese Medicine preparation room and provides for (Lot: black pharmacists word [2004] Z No. 0010). Niaoduqing particles, 5 g / bag, Guangzhou Pharmaceutical Co., Kang Chen produced (batch . adenine, 50 g / bottle, the U.S. AMRESCO company (Lot 0272B31). rabbit anti-rat TGF-β polyclonal antibody, Wuhan Boster Biological Engineering Company. goat anti-rabbit IgG antibody -HRP polymer, Beijing Zhongshan Biotechnology Limited. 1.3 Grouping 60 Wistar mal