Chuanxiong paste paste to accept foreign economic transdermal experiments Selection of Liquid.docVIP

 PAGE \* MERGEFORMAT 11 Chuanxiong paste paste to accept foreign economic transdermal experiments Selection of Liquid [Abstract] Objective To screen the in vitro transdermal experiments Chuanxiong Plaster best accepted solution. Methods TP -5 intelligent transdermal proliferation instrument, in order to Chuanxiong plaster hydrophilic component indicators ligustrazine In order to investigate, using spectrophotometry, to compare different solvent systems Chuanxiong Plaster percutaneous penetration parameters to select the most good acceptance of fluid, for in vitro percutaneous penetration studies lay the foundation for standardization of the experiment. The results of saline and pH 7.4 phosphate buffer solution of the penetration rate constant of the largest J; 10% ethanol / saline, 10% propylene glycol / saline, 10% PEG 400/10% ethanol / saline, 10% PEG 400 / normal saline followed by reduction of J-values. 10% PEG 400 / normal saline transdermal longest delay, pH 7.4 phosphate buffer penetration shortest delay. Conclusion ligustrazine hydrophilic components, the saline or pH 7.4 phosphate buffer solution can be accepted as the best solution. [Keywords:] Chuanxiong paste paste ligustrazine accept foreign economic transdermal liquid Abstract: ObjectiveTo study the receptor fluids of percutaneous permeability of Chuanxiong Adhesive Plaster in vitro and choose a good solution. MethodsTP -5 automatic diffusion apparatus was adopted. Ligustrazine hydrochloride in Chuanxiong Adhesive Plaster was determuined by UV spectroscopy, and the parameters of percutaneous permeability in various fluids were compared. ResultsThe sequence of rate was: NSamp;gt; PBSamp;gt; 10% ETOH / NSamp;gt; 10% PG / NSamp;gt; 10% PEG400/10% ETOH / NSamp;gt; 10% PEG400/NS; the longest lag time was 10% PEG400/NS; the shortest was pH 7.4 PBS. ConclusionSaline or pH7.4 buffered saline solution is recommended for hydrophilic Ligustrazine hydrochloride. Keywords:: Chuanxiong Adhesive Plaster; Lig