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Ciprofloxacin Injection of isotonic sodium chloride regulation
【Key Words】 Ciprofloxacin
Abstract: Using data to reduce the freezing point method, NaCl isotonic equivalent law and the solute molar concentration calculation methods such as three kinds of Ciprofloxacin Lactate Injection 0.2% by adding sodium chloride (NaCl) isotonic adjustment calculation. The results showed that the value obtained is consistent with NaCl, are 0.88g. 0.2% Ciprofloxacin Injection 100ml, respectively, containing NaCl 0.9g, 0.85g should be substandard products, which contain NaCl 0.88g is to meet the requirements of the isotonic solution.
Keywords:: ciprofloxacin injection; NaCl; adjusted isotonic
At present in the domestic market, some drug development companies and wholesale pharmacies selling Ciprofloxacin Injection by adding NaCl content of 0.9%, the report also documents the publication selected the concentration of 0.85%. The author is very clear that injection of the quality requirements must be isotonic solution, ie injection of the plasma osmolality should permeate the same, or will cause adverse reactions, hemolysis, or red blood cell atrophy. So when the main concentration of the drug, when less than isotonic quality requirements, it needs to be adjusted with NaCl, etc., making it isotonic solution. By the same token, in the Ciprofloxacin Lactate Injection by adding NaCl that is for this purpose. Ciprofloxacin Lactate Injection drug concentration in the main 0.2544% (equivalent to Ciprofloxacin 0.2%), and its isotonic concentration should be 12.21%, so less than in part to add NaCl to adjust, but the amount determined by adding the number of ? through several methods used to calculate the following.
Data on a freezing point lowering method [1]
Because ciprofloxacin is 70 to 80 years in the late study of the synthesis of third-generation quinolone antibacterial drugs, in general, the pharmaceutical publications
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