Chronic persistent gastric remnant after ulcer surgery radical changes in the observed tissue molecular pathology.docVIP

 PAGE \* MERGEFORMAT 10 Chronic persistent gastric remnant after ulcer surgery radical changes in the observed tissue molecular pathology [Abstract] Objective To investigate the surgical treatment of chronic persistent gastric ulcer molecular biological mechanisms. Methods 37 patients with chronic persistent gastric ulcer in subtotal resection line (the experimental group and 31 cases of gastric ulcer healing by the second course of treatment (control group in the treatment of whichever gastric tissue before and after, were detected by immunohistochemical protein expression of VEGF and bFGF, factor method labeled endothelial cells, microvessel number. Results chronic persistent gastric ulcer patients before surgery, the gastric tissue VEGF, bFGF and microvessel quantity lower than the control group before treatment (P lt;0.01), after treatment, VEGF, bFGF levels compared with the control group after treatment, little difference (Pgt; 0.05), the level of microvessels in the control group after treatment than after treatment with high ( P lt;0.05). Conclusion chronic persistent ulcer patients after radical surgery, residual gastric tissue VEGF, bFGF expression and microvessel number was significantly positive rate of increase of residual gastric ulcer was enhanced markedly, therefore, chronic persistent gastric ulcer disease should be radical surgical treatment as soon as possible. [Keywords:] chronic persistent gastric ulcer vascular endothelial growth factor basic fibroblast growth factor and microvessel count Recent studies suggest that angiogenesis not only in the wound repair process of gastric mucosa play a role in gastric ulcer occurrence and development also play an important role. Has been proved, and angiogenesis-related vascular endothelial growth factor (VEGF) and the formation of fibrous tissue with the basic fibroblast growth factor (bFGF), in gastric ulcer prevention and healing plays a protective role [1]. To further understand the intra