Closed fracture model in rats Development of the femoral shaft.docVIP

 PAGE \* MERGEFORMAT 6 Closed fracture model in rats Development of the femoral shaft [Abstract] fracture model developed using the new instrument will blow into the SD rat femoral shaft fractures. Transverse fracture 70%, 30% oblique fracture. After 4 weeks of fracture healing rate was 80%. A new instrument in the fracture model combat power, combat positions and aspects of the fracture line and shape control, and can be repetitive. [Keywords:] healing fracture fixation To explore the treatment of fractures of new theories, new treatments, there is a need for a clinical environment close to the animal fracture model [1,2]. We have produced rat closed fracture model of the femoral shaft, very close to the clinical environment, are reported below. Materials and methods Preparation of a fracture model 50 SD male rats weighing 250 ~ 300g. 1.2mm in diameter with a drill to drill into the femoral canal prior Kirschner wire fixation. The femoral shaft in 1 / 3 into the fracture to combat, combat weight of 700g, against height of 10cm, blade and bone pillars of combat plane the minimum distance 1.2mm. 2 imaging analysis of femoral and Anatomy of 50 SD rats were made fracture. Which immediately shot 30 anteroposterior femoral X-ray film, depicting the fracture line form. Corresponding femoral anatomy, also depicts the fracture line shape. measuring intramedullary Kirschner wire and angle of the maximum bending displacement. Another 20 2,4 weeks after surgery, respectively 10 randomly selected the first photo of femoral shaft anteroposterior X-ray films, bone fracture callus formation, no obvious fracture line, defined as fracture healing, fracture healing record the number of animals. Anatomic the femoral shaft, significant fracture callus formation, no unusual activity, defined as fracture healing, fracture healing record the number of animals. 3 results of 30 rats to determine the fracture line form: X-ray film evaluation, transverse fracture