Combined valsartan TwP 1 to 3 chronic kidney disease in diabetic Nephropathy.docVIP

 PAGE \* MERGEFORMAT 9 Combined valsartan TwP 1 to 3 chronic kidney disease in diabetic Nephropathy OF: He Haidong, Wang Wei, Chen Zhen, Zhang Ruzhong [Abstract] Objective TwP combined valsartan treatment of chronic kidney disease (CKD) 1 ~ 3 of diabetic nephropathy (DN), to observe the impact of proteinuria. Methods 60 CKD1 ~ 3 phase patients were divided into treatment group and control group, while oral administration of valsartan capsules 80 ~ 160 mg / d; the treatment group were treated with Tripterygium glycosides 20 mg, 3 times / d, 8 weeks later reduced to 10 mg, 3 times / d, treatment 6 months. before and after treatment of urinary albumin excretion rate (UAER), urinary β2-microglobulin (β2-MG), 24 h urinary protein, fasting blood sugar (FBS), serum albumin (ALB), serum creatinine (SCr), alanine aminotransferase (ALT), glycosylated hemoglobin (HbAlc) were measured for analysis. The results relative to the control group, the combination therapy group, UAER, urinary β2-MG, 24 h urinary protein excretion, SCr and other results were significantly better than the control group , with significant differences (P lt;0.01). and combined treatment group did not find ALB, serum ALT, FBP, HbAlc and other aspects of the control group there was significant difference (Pgt; 0.05). Conclusions Valsartan TwP United Treatment CKD1 ~ 3 期 DN can reduce proteinuria and improve renal function, and delay renal disease progression. [Keywords:] TwP; valsartan; chronic kidney disease; diabetic nephropathy Diabetic nephropathy (diabetic nephropathy, DN) in diabetic ((diabetes mellitus, DM) microvascular complications, is one of leading cause of death in patients with DM. Past studies on the pathogenesis of DN are more concentrated in the kidney disorder of glucose metabolism, lipid metabolism disorders , hypertension, etc., in recent years with the research, the inflammation in the pathogenesis of DN is considered a key link [1], and renin - angiotensin - aldosterone