Dissolving patches of artemisinin.docVIP

 PAGE \* MERGEFORMAT 11 Dissolving patches of artemisinin Of: Wang Naijie, Qiu Lin, Du Feng, Liang Bingwen, Ye Zuguang [Abstract] Objective of the pressure-sensitive adhesive, crystallization inhibitors, screening of penetration enhancers, patches of the soluble form of the prescription process of artemisinin. Methods TK-6A transdermal diffusion device, the SD rat abdominal skin was transdermal barrier to penetration rate of the marker, PSA screening, crystallization inhibitors, penetration enhancers. artemisinin results in the pressure-sensitive adhesive National Starch and the highest penetration rate, PVP K30 crystallization inhibitory effect of artemisinin better penetration enhancers on the penetration effect of artemisinin in the order: propylene glycol (PG)gt; Azone (Azone), the two ingredients, a synergistic effect. Conclusions of the National Starch adhesive, PVP K30, PG + Azone artemisinin were used as dispersed patches of pressure sensitive, crystallization inhibitors, penetration enhancers. [Keywords:] artemisinin, patches, pressure, crystallization inhibitors, penetration enhancers Abstract: Objective To determine the effect of pressure-sensitive adhesives, additives and penetration enhancers on the percutaneous absorption of artemisinin, and study on the formulation of artemisinin transdermal delivery systems. Methods The effects of various additives on the crystallization of artemisinin in polyacrylate adhesive matrix were investigated. The effects of pressure-sensitive adhesives, various additives and penetration enhancers on the in vitro permeation of artemisinin across SD rat abdominal skin were studied. Results National Starch polyacrylate pressure-sensitive adhesive was found to be the most efficient adhesive matrix. PVP -K30 significantly inhibited the crystallization of artemisinin in polyacrylate adhesive matrix. The enhancing effectiveness of the enhancers decreased in the order: PGgt; Azone. PG combined with azone showed a h