海藻光敏色素糖蛋白对乳腺癌细胞侵润转移的抑制作用及信号调控的研究.pdfVIP

海藻光敏色素糖蛋白对乳腺癌细胞侵润转移的抑制作用 及信号调控的研究 钟进义林建维钟宏 (脊鼯大学医学碗，IlI乐费岛266021) 摘要：目的：撵埘海藻嵬敏恕嚣瓣援由(Seaweed photosensitivepigmentglycoprotein，SPPG)对乳麒您细耱经澜转 移的翔制作藕敏鬟；偿蟹调撩机制。方竣：将接种EMT-6乳豫癌细腻豹BAL瑟慰小裁分剐经1：1灌镩给予10、100、 western bwSPPG。述续2w。}；l|iblm和免痰组他等方法梭溯肿瘤缀蠛磷酸他P38MAPK装自、MMP-2 200n蟛kg SPPG维的壤酸 鬣自瓤c-los薮囱瓣畿这水警。绩粜：Western印逑方法竣测躺浆袭明．胂赠瓣’照维和200mg座g SPPG组c-los蛋自阳性 麓黪J均有艇答憔意义(p啪．05)。免疫维化方法检铡c-los鬃良的褒选绦檠强承。200m班g 惟母转导通路的灞化均衡一定的抑傣I蚱豫。 美键漏，礴瑷攀；海藻光皱色豢糖蛋白；錾餍垒耩鬣翻酶一2；P38熬袈媛活纯的缳l耋f激酶 SeaweedPhotosensitive InhibitiveEffectof MetastasisofBreastCancerCellsand of溉 on Study Mechanism Signal-control ZHONG Jinyi，LINJianwei，ZHONGHong (Medical University,Qingdao266021，China) CollegeofQingdao theinhibitivee晌ctofseaweed Abstract：Objective：Toinwestigate photosensitivepigment metastasisofbreast咖cercellsandits mechanism。Methods： glycopmteinfSPpG)on signal-control BA乙B，CmiceinoculatedwimEMT击breastcancercellswere given orally lOm螗g，lOOmg，瞻and 011eea fortwoweeks。the levelsof P38 day 200mg翘SPPG expression phosphorylation mitogen-activatedproteinkinase(P38MAPK)，matrix protein weredetectedwesternblotand Resells：Thelevelsof by immuno-histochemistry． P38MAp粒protein intumorcontrol and SPPG were1．16士-0．18and