Ectopic F1F0 ATP synthase and its relationship with tumor angiogenesis.docVIP

 PAGE \* MERGEFORMAT 24 Ectopic F1F0 ATP synthase and its relationship with tumor angiogenesis Abstract ectopic F1F0 ATP synthase as a cell-surface receptor, it can be expressed in vascular endothelial cell surface adhesion of angiostatin (angiostatin, known as angiostatin), regulation of cell surface ATP levels, thereby affecting vascular endothelial cell the proliferation and differentiation. Angiostatin at low pH, bonding, and can block the cell surface F1F0 ATP synthase, and then interfere with their activities; to take anti-endothelial cells play a strong effect in inhibiting tumor angiogenesis plays an important role. 【Key Words】 endothelial cells Tumor growth and metastasis rely on angiogenesis. With regard to angiogenesis inhibitor drug screening is still the current hot spots. New study of ectopic F1F0 ATP synthase as a vascular endothelial cell surface receptors have been identified. This ectopic ATP synthase catalyzes ATP synthesis, under certain conditions may be angiostatin (angiostatin) inhibition. When the inhibition of angiostatin, the endothelial cells would be difficult to maintain normal intracellular pH, died. An ectopic F1F0 ATP synthase Overview In the mitochondria, through the inorganic phosphate (Pi) and ADP link between the manufacture of a high-energy chemistry with, ATP synthase can be generated by the respiratory chain proton gradient of the energy is converted to ATP. The synthase complex in the past been considered to be strictly expressed in mitochondria inside, but recently many reports that: ATP synthase components are also present in the cell membrane surface, they can serve as a multi-ligand receptor involved in various processes, such as fat metabolic regulation, cell proliferation control, apoptosis, endothelial cell differentiation and tumor immune recognition [1 ~ 3]. The first area of the complex is the membrane F0 region (with c10 ~ c14 ring). The F0 region is a rotary engine, which