Effect of scopolamine on non-cardiac surgery in elderly patients with cognitive impairment in early stage of the incidence of.docVIP

 PAGE \* MERGEFORMAT 6 Effect of scopolamine on non-cardiac surgery in elderly patients with cognitive impairment in early stage of the incidence of [Abstract] Objective: To investigate the preoperative application of scopolamine in elderly patients with non-cardiac surgery under general anesthesia after the early incidence of cognitive dysfunction. Methods: Select the general anesthesia and elective non-cardiac surgery, age ≥ 60 years 121 elderly patients ( male 78, female 43) were randomly divided into scopolamine group and the control group. scopolamine group 10 min before induction of anesthesia, intravenous injection of scopolamine (5 μ g / kg); the control group was given equal volume normal saline, after induction of anesthesia, continuous micro-pump injection of remifentanil and inhalation of isoflurane, intermittent injection of vecuronium to maintain anesthesia. respectively in pre-and postoperative 7th day of neuropsychological assessments, using a Mini-Mental Scale, digit span test, digit symbol test, Tracking connection test and short story memory tests 5 tests. Results: for various reasons, only 64 patients completed all tests, including scopolamine group of 35 patients in control group 29 cases. two groups of patients with height, body weight, gender, years of education and other general information, and the total operation time and anesthesia drugs was no significant difference (Pamp;gt; 0.05). scopolamine group postoperative cognitive dysfunction (POCD) incidence of 25.7% in the control group was 24.1%, was no significant difference between the two groups (Pamp;gt; 0.05). Conclusion: Preoperative intravenous injection of 5 μ g / kg of scopolamine on non-cardiac surgery, POCD in elderly patients with no significant effect on the incidence. [Keywords:] scopolamine; elderly; patients; postoperative cognitive dysfunction Postoperative cognitive dysfunction (postoperative cognitive dysfunction, POCD) after surgery is the orientation, thinking, m