Effect of simvastatin on bone mineral density in osteoporosis of patients.docVIP

 PAGE \* MERGEFORMAT 6 Effect of simvastatin on bone mineral density in osteoporosis of patients [Keywords:] simvastatin, osteoporosis, bone mineral density In recent years, statin drugs on bone growth and the molecular basis of the relationship between research and animal tests, and lipids that are widely used statin drugs have a role in stimulating bone growth, which is looking to bring drugs to treat osteoporosis, a new Research Highlights (1). This observation of statin simvastatin on bone mineral density in elderly patients with osteoporosis impact. 1 Materials and Methods 1.1 Clinical data of 89 cases for the March 2006 ~ July 2007 in our hospital merger of osteoporosis in patients with hypercholesterolemia, aged 60 to 82 (mean 68.3 + -5.0 years old. Including 24 males (mean 70.3 + -5.0 years old, female 65 cases, the average (67.6 + -4.8 years old. divided into a control group of 37 patients, mean (68.1 + -5.0 years old, the treatment group 52 cases (mean age 68.4 + -5.0 .89 patients were found 1995, WHO recommended diagnostic criteria of osteoporosis, bone mineral density (BMD) is lower than the same sex, same race of people young and healthy peak bone mass of 2.5 standard deviations. Hypercholesterolemia as blood cholesterolgt; = 5.69 mmol / L (2). factors of secondary osteoporosis excluded, and the last 3 months, do not use drugs that affect bone metabolism. 1.2 Methods Control group: daily oral elemental calcium 600 mg + Vitamin D 125 IU + lifestyle changes dyslipidemia treatment. Treatment groups: simvastatin 20 mg + daily oral elemental calcium 600 mg + Vitamin D 125 IU. Course of 6 months. introduced to the patient treatment programs, voluntary choice by the patient group, 37 patients in control group, treatment group 52 cases. Treatment before and after treatment were measured blood osteocalcin, collagen series and lumbar spine BMD. osteocalcin and collagen Series by electrochemiluminescence immunoassay method (Roche, equipment,