Effect of simvastatin on the prevention and treatment of osteoporosis in rats.docVIP

 PAGE \* MERGEFORMAT 15 Effect of simvastatin on the prevention and treatment of osteoporosis in rats Of: Yu Wei Li, Wang Shijie, Hanjun Li, Bai Zhilan, Sunhong Hong, Jin Rui, Liu Yan, Zhao Xian [Abstract] Objective of statins in postmenopausal osteoporosis and its associated control mechanism. Methods 40 SD female rats were randomly divided into 4 groups: ovariectomized group (OVX group), the control group (Sham) and 2 Simvastatin (simvastatin, Simv) treatment group, n = 10 .2 simvastatin group was 10,20 mg / kg (S1 and S2 group) orally once a day. observed 12 weeks after surgery indicators of bone formation: osteocalcin (BGP) and bone specific alkaline phosphatase (bone AKP), bone resorption indices: urine pyridine ether (PYD) and deoxypyridinoline pyridine ether (DPD). with histomorphometry, bone biomechanics other experimental techniques to observe the effect of simvastatin treatment. Results after simvastatin treatment, S1 and S2 BGP and bone AKP group was significantly higher than OVX group (P lt;0.05), while decreased urinary PYD and DPD, and S2 group and OVX group, there was significant difference (P lt;0.05). Compared with the OVX group, S1, S2 group trabecular separation (Tb Sp) was significantly lower (P lt;0.05), trabecular bone area percentage (Tb Ar), trabecular width (Tb Th), trabecular number (Tb N), were increased bone biomechanics (P lt;0.05), and between S1 and S2 groups was no significant difference. Compared with the OVX group, S1, S2 femur, lumbar spine BMD increased significantly (P lt;0.05). Conclusion Simvastatin in the prevention of osteoporosis in ovariectomized rats in the process, may also exist to promote osteogenesis and inhibit osteoclast The role of the two. [Keywords:] simvastatin, osteoporosis, bone formation, bone resorption ABSTRACT: Objective To explore the preventive and therapeutic effects of simvastatin on post menopausal osteoporosis and the action mechanism. Methods Totally 40 female SD rats were random