Edaravone on the treatment of ischemic stroke patients and its effects on serum MMP2 and the impact9.docVIP

 PAGE \* MERGEFORMAT 10 Edaravone on the treatment of ischemic stroke patients and its effects on serum MMP2 and the impact9 Of: Wong Chi-Han Pengdao Yong Wang Suping [Abstract] Objective of edaravone on the treatment of patients with ischemic stroke and its effects on serum matrix metalloproteinase (MMP) 2 and 9. Methods diagnosis and treatment of 180 patients hospitalized with ischemic stroke patients were randomly divided into two by edaravone group of 90 patients in conventional therapy plus edaravone treatment, control group 90 patients were treated with conventional therapy; two enzyme-linked immunosorbent assay (ELISA) test before and after treatment and serum MMP 2 9 expression. Results edaravone group total effective rate was significantly higher MMP 2 and 9 after treatment, the decrease value of the more significant (all P lt;0.05). Conclusion Edaravone the effect of the treatment of ischemic stroke significantly and serum can regulate the expression of MMP 2 and 9. [Keywords:] with acute ischemic stroke; edaravone; matrix metalloproteinase-2; matrix metalloproteinase 9 Common clinical ischemic stroke, and high morbidity and mortality, the main treatment is thrombolysis, anti-platelet aggregation, coagulation, improve microcirculation and nerve protection, comprehensive treatment. However, clinical studies have shown that free radicals in the brain injury during development plays an important role in the edaravone can well eliminate free radicals (1). of matrix metalloproteinase family (MMPs) role in the pathogenesis of growing concern (2). In this paper, ischemic stroke edaravone patients with clinical control study, and test before treatment, serum of MMP 2 and 9 expression and to explore its clinical significance, designed to provide the basis for clinical diagnosis and treatment. 1 Materials and methods 1.1 Clinical data from January 2008 to June 2010 diagnosed in our hospital in patients with ischemic stroke in 180 patients, are