Edaravone on septic shock in rats the role of myocardial cell injury.docVIP

 PAGE \* MERGEFORMAT 7 Edaravone on septic shock in rats the role of myocardial cell injury Author: Huo Xiaoping, Gu Xue-lan, LIU Liang-ming, Diao Fang, Chun-Yan Ma, Chen Hui, Li Ping, Lu is the [Keywords:] edaravone; oxygen free radicals; shock, septic; myocardial injury [Abstract] AIM: To investigate the effect of edaravone (ED), a novel free radical scavenger, on cardiac function and myocardial cell injury in rats with septic shock. METHODS: After treatment with three different doses (6.0, 3.0 and 1.5 mg / kg) of ED to rats 1 h after septic shock, changes of MAP, LVESP, LVEDP, ± dp / dtmax were determined in 4 different time phases. The activities of SOD, CAT, LDH and the concentrations of MDA, LD in myocardial tissue were measured. The pathologic change of myocardial tissue was observed by HE staining. RESULTS: Compared with septic shock group, MAP, LVESP and dp / dtmax were increased remarkably in ED treatment groups. The activities of SOD and CAT and the concentration of MDA in ED groups were close to those in normal control group. Histological examination showed congestion, edema and inflammatory cell infiltration in myocardial tissue, while ED treatment attenuated the above pathological changes of myocardium. CONCLUSION: ED has a satisfying therapeutic effect on cardiac dysfunction in rats with septic shock, which may be related to attenuating myocardial injury. [Keywords] edaravone; Oxygen free radicals; shock, septic; Myocardial injury [Abstract] Objective: To observe the oxygen free radical scavenger edaravone (edaravone, ED) on cardiac function in rats with septic shock and myocardial injury. Methods: septic shock in rats after 1 h with three doses of ED (6.0, 3.0, and 1.5 mg / kg) treatment, determination of shock four time points the average blood pressure (MAP), left ventricular end-systolic pressure (LVESP), left ventricular end-diastolic pressure (LVEDP), left ventricular pressure rise and fall The biggest change in rate (± dp / dtmax) a