Elderly type 2 diabetic patients with oxidative stress andcell function.docVIP

 PAGE \* MERGEFORMAT 7 Elderly type 2 diabetic patients with oxidative stress andcell function Of: Yelin Xiu Guo Kun Yang Maoping Qiu all [Keywords:] Type 2 diabetes, oxidative stress, superoxide dismutase Diabetes-related oxidative stress is excessive free radical production and decreased antioxidant capacity of the consequences of long-term effects. Oxidative stress can directly damage islet cells, can also affect the synthesis and secretion of insulin signaling pathway indirect damage cells function (1). This paper aims to study type 2 diabetes (T2DM oxidative stress, and to analyze its relationship with -cell function and related factors, in order to provide the basis for the prevention and treatment of diabetes. 1 Materials and Methods 1.1 General Information 82 cases of T2DM in elderly patients, 42 males and 40 females, aged 60 to 80 (mean (73 + -9.4)) years of age, in line with 1999 WHO T2DM diagnostic criteria, excluding diabetic ketoacidosis and hyperosmolar state, severe stress state, heart, liver dysfunction. healthy control group of 60 patients, 28 males and 32 females, aged 61 to 79 (mean (69 + -7.3 years), inclusion criteria: oral glucose tolerance test normal, with no recent anti-complementary History of oxidant drugs and health products, excluding hypertension, coronary heart disease, infections and other acute and chronic diseases, normal physical examination. the two groups of gender, age, no significant difference. 1.2 Methods Survey subjects were selected for sex, age, disease duration, body mass index, total xanthine oxidase detection of superoxide dismutase (T SOD, located in the mitochondrial manganese SOD (Mn SOD) activity, malondialdehyde thiobarbituric acid method aldehyde (MDA concentration, simultaneous detection of serum total cholesterol (TC, triglycerides (TG, high density lipoprotein cholesterol (HDL C, low-density lipoprotein cholesterol (LDL C, glycosylated hemoglobin (HbA1c, fasting plasma glucose (FP