Endoscopic treatment of esophageal precancerous lesions.docVIP

 PAGE \* MERGEFORMAT 20 Endoscopic treatment of esophageal precancerous lesions Keywords: esophageal cancer; precancerous lesions; Endoscopy; treatment 0 Introduction Esophageal adenocarcinoma esophageal squamous cell carcinoma and precancerous lesions are different. China is a high incidence of squamous cell carcinoma, one of the recent studies have shown that a high degree of squamous epithelial dysplasia (high  grade dysplasia, HGD) should be regarded as precancerous lesions of squamous cell carcinoma [1]. The past 50 years, the Western countries the histological subtypes of esophageal adenocarcinoma to transfer to the main epidemiological investigation that Barrett esophagus (Barrett esophagus, BE) is a precancerous lesion of adenocarcinoma [2]. For the treatment of precancerous lesions of the advanced strategy for the treatment of esophageal cancer, esophageal cancer because not only reduced the back-up group, but also a very early stage esophageal cancer is expected to cure [1]. The past, the main therapy to esophagectomy, but surgical injury, and will the non-cancer pathology results easy to be controversial. At present, the digestive endoscope technology, rapid development, is getting more sophisticated endoscopic treatment of esophageal precancerous lesions is expected to become the mainstream.Endoscopic treatment of esophageal cancer is on the method of precancerous lesions and problems in doing a review. 1 Photodynamic therapy (Photodynamic therapy, PDT) Its mechanism is: photosensitizer by cells (including atypical hyperplasia of the epithelial cells) uptake after a specific wavelength of the irradiation light to produce excited reactive singlet oxygen, to play a direct target tissue cytotoxicity exposure the organization has not been affected. Photosensitizer currently in use are 5  amino acid (5  aminolevulinic acid, ALA), 4-hydroxy chloride (mTHPC), porphyrin Phil sodium (porfimer sodium), and for Mo Park Fen