Fever formation and the rational use of antipyretics.docVIP

 PAGE \* MERGEFORMAT 8 Fever formation and the rational use of antipyretics [Keywords:] fever;,, antipyretics Fever or abnormal elevation of body temperature. Children during the normal body temperature may fluctuate in a certain range, the normal body temperature of liquid in children is generally about 36.0 ~ 37.0 ℃ . The clinical level on the basis of body temperature can be divided into: (1) Low-heat: amp;lt;38 ℃ ; (2) heat: 38 ~ 39 ℃ ; (3) heat: 39 ~ 40 ℃ ; (4) very hot:amp;gt; 41 ℃ . Different types of thermal effects on the human body is different. The human body can maintain a more constant body temperature, mainly due to the hypothalamic thermoregulatory center, through the body’s heat production and heat dissipation mechanism for the coordination to achieve the [1]. Some of the heat due to the formation, as well as to the role of the positive and negative fever do not sufficiently understand the application of antipyretics now the trend has spread, there is need to talk about the formation of fever, as well as the rational use of antipyretic drugs. This paper intends to be introduced from the following aspects. The formation of a fever The formation of internal body heat changes in the environment produced by a reaction, which includes infection, inflammation processes, such as vascular disease, injury repair, as well as the release of immune mechanism of protein fragments, bacterial toxins such as lipopolysaccharide-induced exogenous pyrogen, these exogenous pyrogen to stimulate monocytes and macrophages produce and release of endogenous pyrogen (EP), EP can be delivered into the brain through a specific change of temperature receptors in hypothalamus and discharge frequency, and thus l High-temperature set point (T-set), resulting in increased heat production, heat reduction, body temperature reached a new level, namely, the formation of heat. Two changes in the pathophysiology of fever 2.1 The heat of the specificity, the positive impact of