Functional emphysema lung resection experimental study in dogs.docVIP

 PAGE \* MERGEFORMAT 12 Functional emphysema lung resection experimental study in dogs On: Sun Hong Zhang Hui Zhang Jingyu Xie Chun Yan Zhang Yun Chen Jing Wei Xuewu [Abstract] Objective To investigate the functional limitations of lung resection in dogs treatment of emphysema. Intrapulmonary design and manufacturing methods into one-way vent, select 10 healthy adult hybrid dogs, the use of papain into the establishment of segmental bronchi non-homogeneous type of emphysema in animal models, fiber bronchoscopic placement to the target one-way vent target, monitoring and arterial blood gas analysis, lung CT changes. HE staining frozen sections of lung tissue target. Results 1 dogs died during anesthesia, a pneumothorax occurred, eight replicate successful animal model of emphysema, chest CT showed significantly reduced target lung markings, increased light transmission were successfully placed eight one-way valve at the target lung segment, a fall off into one-way valve 2 w, the target lung tissue, pulmonary atelectasis and opacities. pathologic findings showed alveolar collapse, inflammatory cell infiltration, arterial blood gas analysis in the whole process no significant change. Conclusions Treatment of pulmonary valve into one-way through localized emphysema in dogs is feasible in animal studies, clinical use is expected to promote. [Keywords:] emphysema, functional lung resection, one-way valve, animals Non-homogeneous type of emphysema is a common, progressive development of irreversible airflow limitation, lung pathology terminal bronchioles dilated distal air space and the bronchioles accompanied by destruction of alveolar walls and without significant fiber of the disease. poor outcome of conservative treatment of advanced emphysema. midline incision with bilateral lung volume reduction surgery, unilateral lung volume reduction, assisted thoracoscopic lung volume reduction surgery in recent years, such as treatment of non-homogeneous type of