Fusidic acid against Gram-positive cocci in vitro sensitivity analysis.docVIP

 PAGE \* MERGEFORMAT 12 Fusidic acid against Gram-positive cocci in vitro sensitivity analysis 【Abstract】 Objective To detect the fusidic acid against clinical Gram-positive cocci in vitro antibacterial activity. Methods disk diffusion assay fusidic acid against staphylococci and enterococci antibacterial activity compared with other commonly used antibiotics. At the same time part of the agar dilution assay strain fusidic acid minimum inhibitory concentration (MIC). Results in 121 strains of MRSA 34 Zhu, MRCNS 41 strains, 15 Enterococcus faecalis, 10 Enterococcus feces. Pairs of fusidic acid resistance rates were 2.9%, 4.8%, 100.0% and 100.0%, slightly higher than vancomycin, significantly lower than other commonly used antibiotics (eg, erythromycin, cefazolin, cyclopropane Sand Star, etc.). Fusidic acid on MRSA, MRCNS antibacterial activity was significantly higher than the enterococci. Conclusion fusidic acid on in vitro MRS has high antimicrobial activity. Fusidic acid on Enterococcus no bactericidal effect. Keywords: fusidic acid; Gram-positive cocci; minimal inhibitory concentration (MIC) Staphylococci, enterococci are the most common nosocomial infections caused by Gram-positive bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA) infections caused by increasing brought to the treatment of certain difficulties [1]. At present the best clinical efficacy is commonly used antibiotics vancomycin, there are many new drugs in clinical promoting the use of succession. Fusidic acid (fusidic acid) although already available, but not many in clinical use, the vast majority of foreign reports of its Gram-positive cocci to maintain a good antibacterial activity. We use the disk diffusion method (KB method) to detect fusidic acid on the common clinical strains of Gram-positive nosocomial infections in vitro antibacterial activity and agar dilution method (AD method) to detect some strains of the minimum inhibitory concentr