Gastric cancer and precancerous lesions in the Bcl-2 and Bax gene protein expression and apoptosis.docVIP

 PAGE \* MERGEFORMAT 14 Gastric cancer and precancerous lesions in the Bcl-2 and Bax gene protein expression and apoptosis Authors: DING Hong-ji, Wu Qi Song, Li Gong, Dong Yan light, Ai-Ying Li, Chang-feng, XU Zhi-xiu [Abstract] Objective To study the Bcl-2 and Bax gene protein in gastric cancer and precancerous lesions and to explore its relationship with apoptosis. Methods Immunohistochemical staining method combined in situ TUNEL detection of apoptosis in 70 patients with chronic gastritis, 49 cases of intestinal metaplasia, 64 cases of dysplasia and 81 cases of gastric cancer were Bcl-2 and Bax gene protein detection and in-situ cell apoptosis observed. Results Bcl-2 in moderate and severe dysplasia in the highest rate of positive expression, while moderate and severe dysplasia of the apoptosis index lower. Bax gene protein in intestinal metaplasia and dysplasia in the positive expression rate of slow gastritis and gastric cancer is high, moderate and severe dysplasia of the highest rate of positive expression of Bax. Conclusion Bcl-2 protein expression was negatively correlated with the number of apoptotic cells. Bal-2 expression in gastric cancer may occur early in the process of behavior. Bax for Bcl-2 in suppressing apoptosis function against the regulatory role, both jointly decided whether the cells into apoptosis. [Keywords:] gastric precancerous lesions of apoptosis gene protein The expression of Bcl-2 and Bax protein and relationship between them and apoptosis in gastric carcinoma and precancerous lesions [Abstract] Objective To study the expression of Bcl-2 and Bax protein and explore the relationship between them and apoptosis in gastric carcinoma and precancerous lesions.Methods TUNEL method was used to detect apotosis and immunohistochemical staining method was used to detect the expression of Bcl -2 and Bax protein in 70 chronic gastritis, 49 intestinal metaplasia, 64 dysplasia and 81 gastric carcinoma.Results The positive incidence of Bc