Gliclazide gel-matrix sustained-release tablets.docVIP

 PAGE \* MERGEFORMAT 12 Gliclazide gel-matrix sustained-release tablets [Abstract] Objective To prepare the gel matrix gliclazide sustained-release tablets and to study in vitro release conditions. Methods HPMC as skeleton material, using wet granulation, preparation of gliclazide sustained-release tablets, sustained-release tablets in vitro release study of the impact of factors, and with the reference agents (Servier’s Diamicron MR  ) were compared. Results of gliclazide sustained-release tablets release by HPMC specifications, HPMC consumption, the impact of additional agents, the release curve by f2 (similarity factor) to determine, with the reference formulation similar to. Conclusion The agents prepared prescription reasonable and technology is feasible, in vitro release behavior and Diamicron MR  similar. [Keywords:] Gliclazide body gel matrix tablets release Release Abstract: Objective To prepare the sustained  release hydrophilic matrix tablets of gliclazide. Method The HPMC matrix tablets of gliclazide were prepared with the wet method, using hydroxypropyl methycellulose (HPMC) as the matrix material. The release profile was investigated with the dissolution test and compared with that of Diamicron MR  . Results The samples had the similar sustained  release property with that of Diamicron MR  and the release rate was influenced by formulations and processing factors, such as HPMC content, type of HPMC, presence of additive and so on. Conclusion This formulation is rational, the preparation procedure is simple, and the in vitro release property is similar with that of Diamicron MR  . Keywords:: gliclazide; hydrophilic matrix tablets; drug release rate Diabetes is second only to cardiovascular and cancer after the threat to human health, the third biggest killer, WHO on the report as early as in 1997 there are 135 million people worldwide suffer from diabetes, is expected to reach 240 million will be in 2010. The incidence of diabetes i