High altitude of recombinant human brain natriuretic peptide in patients with chronic heart failure observation.docVIP

 PAGE \* MERGEFORMAT 8 High altitude of recombinant human brain natriuretic peptide in patients with chronic heart failure observation Of: Zhang, Qing Wu Hong Ma Haiying Li Shunyan [Keywords:] brain natriuretic peptide, chronic heart failure, the elderly, high altitude Long-term excessive neurohormonal activation in chronic cardiac insufficiency (CCI) progressive deterioration of the important reasons. Clinical studies, brain natriuretic peptide (Brain natriuretic peptide, BNP) on the CCI has important diagnostic and prognostic value of (1). at home and abroad in recent years to CCI patients treated synthetic BNP (2), but not yet in use of high altitude experience. This article explores rhBNP CCI at high altitudes in the safety of patients and the patients with renal insufficiency of . 1 Subjects and methods 1.1 Object Select June to December 2008 in the undergraduate admission 10 patients with CCI, 8 males and 2 females, aged 79 to 88 years, with an average age of 85. Inclusion criteria: patients with heart failure Symptoms “6 months, cardiac function points grade-level standards in accordance with New York Heart Association (NYHA) severe heart failure ( ~ grade), to continue the original treatment of angiotensin-converting enzyme inhibitors or angiotensin receptor antagonist and blocker agent. except for systolic blood pressure continued to lt;85 mmHg, in the past or plan to line organ transplant (heart, liver, kidney), unwilling or unable to accept the continuous intravenous injection of persons, within 1 month history of cardiac pacemaker implantation, have left ventricular implant, cardiogenic shock and so the secretion of BNP, is expected to continue dialysis or dialysis in the treatment of patients that will be on rhBNP allergic patients, requiring immediate treatment of acute heart failure patients, 1 month, new myocardial infarction patients. 1.2 Methods Patients with continuous intravenous injection of rhBNP (Biological Phar