IL 23 biological activity and the relationship between inflammatory disease Research.docVIP

 PAGE \* MERGEFORMAT 19 IL 23 biological activity and the relationship between inflammatory disease Research Keywords: interleukin  23 immunization nasal A IL  23 (IL  23) is a Oppmann, etc. [1] in 2000 found an interleukin  12 (IL  12) cytokine family, a new member with IL  12, are both contained p40 subunit of the heterodimer of cytokines, and their functions overlap but each is different. We are on the IL  23 in inflammatory diseases of the status quo are reviewed. 1 IL  23 Structural Molecular Biology IL  23 is a p19 and p40 subunits by disulfide bond formation of heterodimers of molecular structure of p19/p40, either a separate sub-units do not have the biological activity, only two sub-units integrated in together, in order to perform its biological function. Michael et al [2] from the sequence database to find IL  6 new sub-family members, found a new cell factor p19, its mouse and human cDNA sequences encoding the respective amino acids 189/196 peptide molecular weight was 18.7? ku, and 19.8? ku. Human and mouse p19 with 70% homology. The expression of p19 alone can not efficiently secreted by cells, it is speculated that p19 needs a chaperone protein for secretion, and as a subunit of cytokines play a role. Later, Frank et al [3] In the study of IL  12 genes and found the lack of a mouse model, p40-deficient mice with p35-deficient mice, a single spore of the bacteria Listeria monocytogenes susceptibility different. P40-deficient mice in which disease phenotype is very serious while the same function as the IL  12 subunit p35 gene knockout mice are less severe, suggesting that p40 addition to serving as IL  12, a sub-unit is also involved in other functions outside the complex formation and play a role. Klaus et al [4] In the study of IL  12 mice genetically lacking in resistance to the cryptococcal also found, p40-deficient mice with p35-deficient mice on the different susceptibilit