Ischemic Preconditioning on Myocardial Infarction in Rats hepatocyte growth factor expression.docVIP

 PAGE \* MERGEFORMAT 14 Ischemic Preconditioning on Myocardial Infarction in Rats hepatocyte growth factor expression Of: Han Ying Li Xiaohui Xing Ying ZHAO Xiao-Yun Zhang Ping field [Abstract] Objective To observe the remote myocardial infarction and ischemic myocardium after ischemic preconditioning, hepatocyte growth factor (HGF) gene expression in the changes of HGF in the remote ischemic preconditioning. Methods Experimental groups : acute myocardial infarction; lower limb ischemic preconditioning group: bilateral femoral artery occlusion followed by reperfusion, repeated four times after the ligation of left anterior descending artery. renal ischemic preconditioning: bilateral renal artery occlusion and reperfusion Repeat 3 times left anterior descending artery ligation. control group. distinguished by evans TTC staining, infarcted and ischemic myocardium, infarcted myocardium was cut and ischemic myocardium and weighed. detected by RT PCR in rats lacking Cardiac HGF mRNA expression in the blood area. Results addition to the normal control group, the other three groups showed no significant difference in ischemic; and myocardial infarction in renal ischemic preconditioning group level (46.18% + -6.15%), lower limb ischemic preconditioning group infarct (46.92% + -6.69%) than in patients with acute myocardial infarction (66.44% + -13.68%) were lower compared to about 30% (P lt;0.05). renal ischemic preconditioning group and lower limb ischemic preconditioning group 4,6 , 12 h HGF mRNA expression in acute myocardial infarction than the group at each time point reduction (P lt;0.01). Conclusions The results suggest that HGF may be remote ischemic preconditioning reduces infarct area of one of the mechanisms. [Keywords:] Acute myocardial infarction; ischemic preconditioning; hepatocyte growth factor Gho and other findings in 1996 the small intestine or renal ischemia 15 min of coronary occlusion 60 min of the cardioprotective effect, can signi