CF加5-Fu持续滴注联合CBP治疗晚期食管癌.pdfVIP

肺癌防治研究 2006 茸第 33 卷第 11 期 ? 829 ? CF 加 5-Fu 持续滴注联合 CBP 治疗晚期食管癌 江 艺，邱希辉，杨伍贤，林丹霞，张盛奇 High-Dose-Folinic Acid ，于f1 uorouracil Bolus and Continuous Infusion 48 Hours Combined with Carboplatin in Advanced Es叩hageal Carcinona JIANG Yi , QIU Xi-hui , YANG Yu-xian, LIN Dan叹ia ， ZHANG Sheng-qi Deρα rtment 01 Medical Oncology , lA1ncer Hospital , Shantou University School 01 Medicine , Shantou 515041 ,China Ahstract:Objective To assess the ant? tumor efficacy and safety of high-doSEγfolinic acid plus 少 fluorou- racil bolus and continuous infusion 48 hours combined with carboplatin in treating advanced esophageal carcinoma. Metb创fs 33 patients with advanced esophageal carcinoma were treated with high-dose-íolinic acid plus 少 fluorouracil bolus and continuous infusion 48 hours combined with carboplatin. Rωults There were 3 complete respone, 12 partial respone, 17 no changes and 1 progressive disease in this series with total response rate of 45. 45%. 1、he main side effects include nausea and vomiting, alopecia, bone marrow suppression and mucositis. Other side effects were uncommon. All side effects were tolerable, after treatment the patients were seen making progress. Conclusion High-dose- folinic acid plus 5-flu orouracil bolus and continuous infusion 48 hours combined with carboplatin may be a safe and effectiv伫 therapy for the patients with advanced esophageal carcinoma. Key words:Advanced esophageal carcinoma; Chemotherapy; Leucovorin; 5-Fu; Carboplatin 摘 要:目的 评价大剂受膝氮叶酸加 5 氟尿啼唆 (5-Fu) 持续 48h 滴泳联合卡钩 (CBP) 方案治疗晚期 食管癌的客观疗效及毒副反应，探索晚期食管癌较合理治疗方案。方法 对入选的 33 例晚期食管癌病 人采用大剂堂峪氢叶酸 C200mg/m2 ) + 5-FuC3. 0 g/时)持续 48h i尚泳联合 CBP 方案进行治疗，平均 2.61 个疗手里。结果 究会缓解 (CR)3 例，部份缓解 (PR) 12 例，稳定