Metformin and clomiphene citrate treatment of polycystic ovary syndrome insulin resistance combined analysis of 30 cases.docVIP

 PAGE \* MERGEFORMAT 7 Metformin and clomiphene citrate treatment of polycystic ovary syndrome insulin resistance combined analysis of 30 cases [Abstract] Objective: To investigate the treatment of metformin combined with clomiphene polycystic ovary syndrome (PCOS insulin resistance (IR infertility treatment. Methods: The oral administration of metformin combined with clomiphene citrate, 30 cases of PCOS IR infertility treatment, observation patients in each group before and after the body mass index, fasting insulin, fasting glucose, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, progesterone, testosterone levels and ovulation effects of comparison. Results: before and after, body mass index, fasting insulin, LH and FSH ratio, testosterone was significantly decreased compared with the treatment, the difference was statistically significant (P lt;0.05, IR status improved significantly after treatment, ovulation rate was 86.7%. Conclusions: Oral metformin grams Luo Mifen can improve the state IR PCOS patients to reduce insulin, sex hormone abnormalities in patients with reversal of PCOS, PCOS significantly improved the sensitivity of clomiphene citrate, clomiphene ovulation induction to improve the therapeutic effect. [Keywords:] polycystic ovary syndrome, metformin, clomiphene citrate, insulin resistance Polycystic ovary syndrome (PCOS is a common endocrine disorders. Recent studies show that, PCOS patients were either obese or not, there are different degrees of insulin resistance (IR and hyperinsulinemia, insulin sensitizing agents can reduce the peripheral blood insulin levels, while reducing the level of male hormones, and to improve ovulation in patients with PCOS [1]. Metformin is the treatment of type 2 diabetes, the drug increased insulin sensitivity [2], metformin has been applied to more than 40 years of clinical, belonging to B drugs. select from April 2004 to December 2007 in our hospital gynecology clin