Minocycline in the skin of the rational application of STD.doc

 PAGE \* MERGEFORMAT 24 Minocycline in the skin of the rational application of STD Minocycline (minocycline, Minocin, Minocycline, minocin) Department of second-generation tetracycline, it is a semi-synthetic tetracycline, the chemical name 7 - dimethylamino -6 - to methyl -6 -- deoxy-tetracycline. For the treatment of sensitive bacteria caused by a variety of mild to moderate infections, a better clinical efficacy. A general pharmacological effects〕 〔1 ~ 2 Minocycline as a broad-spectrum antibiotics, and tetracycline have similar pharmacological effects, but the effect stronger. 1.1 Antibacterial: The Gram-positive bacteria and-negative bacteria in particular sensitive to tetracycline-resistant strains; pairs of aerobic and anaerobic bacteria have antibacterial activity; In addition to the mycoplasma, chlamydia is also inhibited. Minocycline is mainly bacteria, but high concentrations, a bactericidal effect. 1.2 inhibit lymphocyte activity: Minocycline significantly inhibited lymphocyte phytohemagglutinin (PHA) for mitogen-induced response reaction; 1.3 Anti-inflammatory: Minocycline can inhibit neutrophil chemotaxis and inhibition of oxygen intermediates involved in the role of inflammation; 1.4 anti-collagenase activity: collagenase activity depends on calcium and zinc, minocycline, through its chelation of calcium and zinc affect the level of play. 1.5 inhibit sebum secretion: Minocycline significantly reduces facial skin and free fatty acid levels, with the extension of treatment time, reduce the amount of free fatty acids more able to maintain that role after stopping. 1.6 pairs of the role of protein metabolism: by blocking amino-mercapto-S-RNA and RNA ribosome complex combination impede protein synthesis. 1.7 affect cell adhesion: Minocycline at doses of less than 100μg/ml, when to increase the adhesion of gingival fibroblasts and elongation