Millettia extracts on the anti-tumor effect and influence on hematopoietic.doc

 PAGE \* MERGEFORMAT 11 Millettia extracts on the anti-tumor effect and influence on hematopoietic Of: Fu Qi, Luo Xiaoqin, Tang Yong, Yang Guowang, He Wei, Wang Xiaomin [Abstract] Objective To study in vivo Millettia extract (SSCE) and the anti-tumor effect of hematopoietic function. Methods of transplanted Lewis lung cancer model in mice, the inhibitory effect observed in vivo SSCE and peripheral blood by detecting, Bone marrow smears were observed on the hematopoietic function of tumor-bearing mice. The results SSCE inhibition rate reached 30.65%. SSCE can promote the proliferation of bone marrow, and the chemotherapy drug combination chemotherapy can reduce bone marrow suppression, while the physical tumor-bearing mice state is not affected. Conclusion SSCE with cancer, the dual role of stimulating hematopoiesis with the chemotherapy drug combination can reduce the bone marrow suppression. [Keywords:] Millettia extracts, anti-tumor, Lewis lung carcinoma cells, hematopoietic Keywords:: extract of Spatholobus suberctus Dunn, antitumor, Lewis lung carcinoma cell, hematopoiesis Millettia nourishing blood is commonly used drugs, commonly used in clinical medicine in the treatment of patients with advanced cancer in the blood stasis [1]. Abroad has been reported, Millettia separate components can induce tumor cell apoptosis and tumor metastasis [ 2]. Early experiments confirmed that Millettia Water Extract of 6 kinds of tumor cell lines with anti-proliferative effect [3], on this basis, further use of polyamide column chromatography and gradient elution method of ethanol from aqueous extract of Millettia isolated compounds SSCE, on the A549 cells in vitro killing effect significantly, 24 h efficacy of the strongest, IC50 value of 25.54 μg / mL. Early in vivo experiments found that the inhibition of its strong rate of determine the optimum dose. this experiment to select the dose as the therapeutic dose, while hematopoietic function of mice was dete