MMP9 gene polymorphism with arterial stiffness in elderly Correlation.doc

 PAGE \* MERGEFORMAT 14 MMP9 gene polymorphism with arterial stiffness in elderly Correlation On: Sun Ying Lu Fang Hong Sun Shangwen Zhaoying Xin Shu-Jian Zhen-Dong Liu Wen Peie [Abstract] arterial stiffness in elderly and matrix metalloproteinase 9 (MMP 9) gene polymorphism. Methods 437 elderly patients (aged 60 to 95 years) In general, laboratory parameters, and brachial-ankle pulse wave velocity (ba PWV) in the detection and comprehensive baPWV value and age of ba PWV curve, divided into low and high baPWV group baPWV group. application of PCR restriction fragment length polymorphism (RFLP) method to determine genotypes, analysis and comparison of the two group of three genotype MMP 9. Results of high baPWV TT genotype group (16.4%) was significantly higher than the low baPWV group (8.8%) difference was statistically significant (2 = 6.470, P = 0.008) . T allele distribution of the two groups was significant (2 = 7.929, P = 0.003). MMP 9 in the three genotypes C / C type as the comparison baseline, C / T-type and T / T OR type were 1.227 (95% CI: 0.793 ~ 1.899) and 2.170 (95% CI: 1.184 ~ 3.976). C allele as compared to baseline, T allele OR = 1.550 (95% CI: 1.141 ~ 2.105) . by a single factor non-conditional Logistic regression analysis, multivariate non-conditional Logistic regression analysis showed that age, body mass index, systolic blood pressure, pulse pressure, mean arterial pressure, smoking, high density lipoprotein (HDL) and MMP 9 TT genotype increased risk of arterial stiffness factor. Conclusions Elderly arterial stiffness and MMP 9 gene is closely related to, MMP 9 gene 1 562T allele may increase arterial stiffness in the elderly one of the genetic marker. [Keywords:] Aged; arterial stiffness; matrix metalloproteinase-9; gene polymorphism Matrix metalloproteinase 9 (MMP 9) is a family of matrix metalloproteinases (MMPs) in the gelatinase A, as the degradation of vascular basement membrane collagen in the main enzymes, and arterial s