More bang for the early burn wound nitric oxide endothelin malondialdehyde.doc

 PAGE \* MERGEFORMAT 8 More bang for the early burn wound nitric oxide endothelin malondialdehyde Author: Cheng Chun-Ying, Wang Jun, Tang Yin-Juan, Luo flocks 【Abstract】 Objective To investigate a new burn dressing “more bang” on burn wounds possible mechanism. Methods of deep Ⅱ ° burn model in rats in the experimental group in order to more bang for external use dressing, the control group to 1% SDAg bandaged, and control group without any drugs, were measured pre-injury skin, 3,6,12,24 h after injury in each group wound in the NO, ET-1 levels, as well as pre-injury skin, 6,24 h after injury, wound MDA content in each group and calculate the ratio of each group ET-1/NO. Results In the experimental group, the wounds ET-1, NO, MDA levels compared with the control group and blank control group were low, the ratio of the experimental group compared with ET-1/NO blank control group and the control group was low, and the earlier it tends to pre-injury ratio. Conclusion more bang burn wound dressing may be by regulating the ET-1, NO content, optimize ET-1/NO ratio, thereby reducing the wound tissue lipid peroxidation damage; and its role is better than silver sulfadiazine. Keywords: more states; nitric oxide; endothelin -1; MDA 【Abstract】 Objective To study the influence of Yubang in the wound after thermal injury.Methods SD seventy-eight rats (250g ~ 300g) of both sexes were randomly divided into 4 groups.One group (n = 6) was served as nonburned control and the content of nitric oxide (NO), endothelin-1 (ET-1) and MDA in the back skin was measured after exposed to 37 ℃ water for 20 seconds, then the ET-1/NO was calculated.The other groups were exposed to 80 ℃ water for 20 seconds resulting in a deep second degree burn involving about 20% surface area.In the 2nd group, nothing was used to protect the wound and it served as blank control group.The 3rd group was used the 1% SDAg to protect the wound and served as control group.The 4th g