Multiple concussions on cognitive behavior and the impact of dopaminergic neurons.docVIP

 PAGE \* MERGEFORMAT 11 Multiple concussions on cognitive behavior and the impact of dopaminergic neurons Of: Xu Gang Jiang Yuesheng on the construction of cloud SOCIALIST Wu Chunyun [Abstract] Objective To investigate the multiple concussion (MCC) and cognitive behavior in rats of dopamine (DA) neurons changes. Methods copying device with a metal pendulum against MCC rats were randomly divided into control group and 1 injury ~ 24 d6 an injury group; application of Morris water maze test, evaluation of learning and memory in rats, using immunohistochemistry and image analysis method to study brain injury in the substantia nigra area (SNC), ventral tegmental area (VTA) changes in DA neurons and tyrosine hydroxylase in the light microscope (TH) positive cells were counted. results in the water maze test, 16 d after injury, the rats to escape to find the platform significantly longer; in the absence of Platform detection experiments, 8,16 d after injury, rats in the original platform of the third quadrant time was significantly reduced. In immunohistochemistry experiments, SNC DA neurons after injury 4,8 d expression was significantly higher; VTA was significantly higher in the 2,4,8,16 d (P lt;0.05). Conclusion rats had multiple concussions are more severe cognitive impairment; injury in rats after SNC, VTA DA neurons express different degrees the increase. [Keywords:] multiple concussion; Morris water maze; dopamine; rat High incidence of concussion, multiple complications (1,2). At present, domestic and foreign to the simple concussion cognitive behavior of many animals, but the common movement of the medical profession and related multi-concussion cognitive Behaviors of lack of coverage. Some scholars have used fluid percussion brain injury model replicated many times (3,4), but the method requires the animal awake and not under anesthesia, not exactly used to study the sports-related concussion Injuries and damage mechanisms. In this study, multip