Nerve growth factor receptor TrkA expression in the central nervous system distribution and role of the.doc

 PAGE \* MERGEFORMAT 14 Nerve growth factor receptor TrkA expression in the central nervous system distribution and role of the Keywords:: TrkA ChAT in basal forebrain of Alzheimer’s disease estrogen Abstract tyrosine kinase (tyrosine kinase, TrkA) is a nerve growth factor (nerve growth factor, NGF) receptor function. Choline acetyltransferase (choline acetyltransferase, ChAT) is the cholinergic neurotransmitter acetylcholine synthesis of key enzymes. During development of rat basal forebrain TrkA, ChAT expression of certain laws, aging rats and patients with Alzheimer’s disease basal forebrain TrkA, ChAT expression was significantly reduced. TrkA, ChAT estrogen receptor co-exist in basal forebrain neurons. Female hormones for the rat basal forebrain TrkA, ChAT to play a role in the maintenance of normal levels. Female hormone replacement therapy in postmenopausal women can help reduce their likelihood of suffering from Alzheimer’s disease. Keywords:: TrkA ChAT in basal forebrain of Alzheimer’s disease estrogen Nerve growth factor (nerve growth factor, NGF) is a classical neurotrophic factor. NGF in the peripheral nervous system (peripheral nervous system, PNS) involved in sympathetic neurons, neural crest origin of sensory neuronal development, survival, maintenance and damage repair role has gradually been recognized. Bashi Nian later, it was discovered that NGF on the central nervous system (certral nervous system, CNS) in the basal forebrain (basal forebrain) cholinergic neurons play a role. While acting on the Department of cholinergic neurons in NGF mainly by the target areas (hippocampus and neocortex) produces, after retrograde transport to cholinergic neurons play a role in its target-derived nutrients. A large number of studies have shown that subsets of these neurons in learning and memory has a special function. In cultured PC12 cells in the culture medium by adding NGF, can induce PC12 neurite growth and to increase enzyme activity, but in