OAD combined with the premixed insulin glargine treatment of type 2 diabetic patients compared.doc

 PAGE \* MERGEFORMAT 10 OAD combined with the premixed insulin glargine treatment of type 2 diabetic patients compared Of: Yang Qiao Ling, Huang Jianning, Yang Ruiying [Abstract] OAD compared with poorly controlled type 2 diabetes, combined day 1 and the use of insulin glargine injected daily injections of premixed insulin 2 times the therapeutic effect and safety of 78 cases of oral hypoglycemic agents are not blood glucose control ideal of type 2 diabetes were randomly divided into two groups, one group OAD + glargine treatment group (n = 40), another group of disabled OAD, use 2 times daily injection of premixed insulin (Novolin 30R 30 % short-acting, 70% in effect) (n = 38), 12 weeks after treatment compared two groups of glycated hemoglobin (HbA1c), fasting blood glucose (FBG) and postprandial 2 h blood glucose (2 h PG) changes, low blood sugar The incidence of two groups of patients HbA1c 7% share. Results After treatment, OAD + glargine group FBG, 2hPG, HbA1c decreased significantly than that before treatment (P lt;0.01), premixed insulin group FBG, 2hPG, HbA1c compared with treatment the former decreased (P lt;0.05). treated the two groups, OAD + glargine group FBG, 2hPG, HbA1c decreased more significantly (P lt;0.05). O AD + insulin glargine group was lower than the body fat of low blood sugar premixed insulin group (P lt;0.05), and the OAD + insulin glargine group had more patients achieved HbA1c 7% (31.6% VS 15.0%). on the basis of oral hypoglycemic agents, the joint day 1 of insulin glargine in type 2 diabetes as The initial treatment of insulin more effective and safe. [Keywords:] insulin glargine; 2 diabetes mellitus; glucose Insulin glargine is the use of recombinant DNA technology, using non-pathogenic Escherichia coli strains produced acid injection in completely dissolved, the solution was colorless and transparent form, can be used for injection. And in physiological conditions, the solubility of the very low, being in the acidi