Nylestriol Progress in Research and Application.doc

 PAGE \* MERGEFORMAT 16 Nylestriol Progress in Research and Application Abstract: The Nylestriol (CEE3) in recent years, experimental research, application profiles, mainly including anti-radiation research, osteoporosis research and treatment of climacteric syndrome, lowering blood pressure, removal of IUD results. Nylestriol (Nilestriol) is a long-acting formulations of estriol, oral absorption, stored in adipose tissue metabolism in the body of acetylene estriol and estriol to play a role is the role of weak estrogen. Has been used for the clinical treatment of menopausal syndrome, in recent years, some people CEE3 conducted other research. Such as anti-radiation, prevention and treatment of osteoporosis, the effects on blood lipids and the removal of IUD and other gynecological. Are summarized as follows: An anti-radiation 〔1〕 3,10,11 With 60Co r-ray irradiation experiment with mice found that CEE3 can not only improve the survival rate of irradiated mice, their hematopoietic system has significantly improved. Studies have shown that: CEE3 right 8Gy irradiated mice by peripheral white blood cells, within the exogenous spleen and bone marrow granulocyte progenitor cells, bone marrow and bone marrow hematopoietic indicators outside the marked increase in the role. Resulted in normal mice bone marrow cells from G0/G1 phase to S phase transformation, so that the proportion of S phase cells increased significantly. According to another report: Bone marrow transplantation for treatment of leukemia and malignant lymphoma, one of the key factors are used in radiotherapy or chemotherapy dose to maximize kill tumor cells, but also allows hematopoietic reconstitution. Studies have shown that, CEE3 can promote hematopoiesis in mice with bone marrow transplantation reconstruction, showed elevated white blood cells, multipotential hematopoietic stem cells and bone marrow granulocyte progenitor cells is higher than those who did not use